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Application Database Layer Generator
Kuboš, Jaroslav ; Rychlý, Marek (referee) ; Burget, Radek (advisor)
This diploma thesis deals with the design and implementation of a framework for the database persistence layer development. This framework is easy to use while keeping the code elegance. It supports object oriented programming features such as inheritance and collections. Other features include versioning of objects and lazy loading. The object metadata are obtained through reflection provided by the .NET framework. The framework is not using any literal for identification (classes, attributes) even in object queries. Most of checks are done by compiler.
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Changes in distributional range and ecology of bats realated to climate change
Pavlíková, Barbara ; Lučan, Radek (advisor) ; Bartonička, Tomáš (referee)
In the last few decades bats are affected by climate change. Changes in average temperatures affect their morphology, phenology, diversity and distribution. Changes in biotopes caused by anthropogenic influences are responsible for the loss of shelters and connectivity of habitats. Empirical data show us that the range expansion of many bat species are gradually shifting to higher latitudes or altitudes. Mathematical models predict that the bat diversity and richness around the world will decline. Some species will shift their ranges and some will shrink their range or even become extinct. Key words: chiroptera, bats, range shift, bioindicators, climate change
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Swarming and hibernation of bats in scree fields and talus slopes
Legát, Jakub ; Lučan, Radek (advisor) ; Andreas, Michal (referee)
This literature review attempts to summarize the knowledge on swarming of temperate bats. It focuses on the characteristics of the term swarming and the history of research on this behaviour in the Czech republic and worldwide. It describes in some detail the species that participate in this behaviour, defines the period when bat swarming take place and discusses the factors that influence this behaviour. The second part of the paper summarizes information on swarming and hibernation of bats in scree fields and talus slopes. However, there is very little information to date on whether and in what quantities bats use this habitat during swarming and hibernation period. This thesis discusses existing surveys on this issue and is designed as a theoretical overview for the field research that author intends to undertake during his master's degree.
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Potential role of opioids in neuroprotection
Gebauer, Martin ; Novotný, Jiří (advisor) ; Rudajev, Vladimír (referee)
The opioids have been used by mankind for more than two millennia, but effect and mechanism of their action on the cells has been unveiling in the last few decades. The mechanism itself is often still unknown, but its effect is observed only. There are several groups of opioid receptors which are able to bind opioids. These groups are characterized by their differe nt affinity to opioids, in some cases by their different effects on cells and by their representation in the various areas in the CNS. Thus, the effects induces by these opioid are very different in many cases. This thesis summarizes the current knowledge about coronary heart disease and the potential of opioids for the prevention and their effect during ischemia, also summarizes the effects of morphine on the CNS. During ischemia δ-opioid receptors play a major role, because they inhibit or block the proapoptotic effects of ischemia on many levels. These receptors are also involved in inducing and maintaining the animal hibernation and protect animal's body against very harmful effects of hibernation, e.g lack of oxygen and nutrients. Morphine is opioid which has been used as anesthetic for longest time. It is well-known opioid and it has the most known derivates. This thesis also summarizes most significant effects of morphine on...
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The photoperiodism and hibernation
Pařezová, Lucie ; Bendová, Zdeňka (advisor) ; Weissová, Kamila (referee)
Many organisms living in seasonal environments use annual changes in the length of the day for timing of their responses, such as reproduction, migration or hibernation. Hibernation allows animals to survive difficult periods associated particularly with cold temperatures and lack of food resources. This adaptation requires many physiological, morphological and behavioral changes. Some of these changes take longer, so their right timing is crucial. For most hibernators in temperate regions shortening of the photoperiod is the most reliable signal for initiation of these changes. This work describes the transduction of photoperiodic information to the melatonin signal, its effects in the pars tuberalis and the significance of this structure in seasonal physiology. A more detailed description is devoted to hibernation, and in the last chapter there is briefly mentioned photoperiodism in nonhibernating organisms. Powered by TCPDF (www.tcpdf.org)
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New findings of physiological and ecological aspects of hibernating bats
Ungrová, Zdislava ; Jahelková, Helena (advisor) ; Lučan, Radek (referee)
Bats can be found in almost all climatic zones. They have to deal with unfavorable conditions of environment to survive and reproduce sucessfully. Especially in temperate zones they have to deal with cold temperatures and lack of food during a winter season. To save energy bats enter a short, diurnal torpor or a hibernation. Usually, hibernation lasts all winter and is disturbed by short bouts of arousals. During both hibernation and torpor a physiological changes occur in bodies of bats. Body temperature decreases from endothermic levels, metabolic rates are reduced as well as respiratory rate and pulse. These changes are mainly influenced by weight and body size, diet, ambient temperature, sex and reproductive status. With the developement of new technologies, these changes can be measured more accurately than they have been in past, whether in a field or in a laboratory. But not all physiological processes are well explained. We have little knowledge especially about mechanism of arousal from hibernation. During awakening bats are infected by fungus Geomyces destructans that affects their immune system. In Norh America fungus causes a disease called White- Nose syndrome (WNS), that is responsible for death of millions of bats, especially endangered is Myotis lucifugus. In Europe, this disease is reffered...
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Role of post-translational modifications, O-GlcNAcylation and Phosphorylation, in neurodegenerative disorders and brain hypometabolism
Špundová, Tereza ; Růžička, Jiří (advisor) ; Čočková, Zuzana (referee)
Post-translational modifications are major mechanisms that highly increase the variability in protein function. O-GlcNAcylation and phosphorylation are among the most extensively studied post-translational modifications in research to date. In physiological conditions, O- GlcNAcylation acts as a metabolic sensor that links glucose metabolism to normal neuronal functioning. Reversible phosphorylation is one of the mechanisms that can downregulate metabolism by regulating the rates of flux through metabolic pathways. The impairments in the regulation of these modifications are linked to with neurodegenerative disorders and hypometabolism. This thesis focuses on the crosstalk and correlation between these two modifications, their reciprocal relationship and their mutual impact on their regulations in models of neurodegenerative diseases and disease non-related models. Keywords: hypometabolism, O-GlcNAcylation, phosphorylation, post- translational modifications, neurodegenerative disorders, hibernation, caloric restriction, memory, learning
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The photoperiodism and hibernation
Pařezová, Lucie ; Bendová, Zdeňka (advisor) ; Weissová, Kamila (referee)
Many organisms living in seasonal environments use annual changes in the length of the day for timing of their responses, such as reproduction, migration or hibernation. Hibernation allows animals to survive difficult periods associated particularly with cold temperatures and lack of food resources. This adaptation requires many physiological, morphological and behavioral changes. Some of these changes take longer, so their right timing is crucial. For most hibernators in temperate regions shortening of the photoperiod is the most reliable signal for initiation of these changes. This work describes the transduction of photoperiodic information to the melatonin signal, its effects in the pars tuberalis and the significance of this structure in seasonal physiology. A more detailed description is devoted to hibernation, and in the last chapter there is briefly mentioned photoperiodism in nonhibernating organisms. Powered by TCPDF (www.tcpdf.org)
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Reproductive biology of brown frogs of the Czech Republic
Žáčková, Lucie ; Šandera, Martin (advisor) ; Vojar, Jiří (referee)
The frog reproduction biology is species-specific. Most of them, searches for water environment for reproduction. Our true frogs are no exception, they can be found in water right on the beginning of spring. For the rest of the year, the move on the land and only return to water when they intend to enter hibernation. They are also sometimes named as "land frogs" due to them spending most of their life in terrestrial environment. The true frogs look very similar and for their definition the combination of more determining attributes is used. The coloration of both sexes differs depending on time of the year in different species. The differences between males and females, but also between different species, are visible the most during the reproduction phase. Apart from coloration there are many other different characteristics. One of those is the calling of males in reproduction phase. Moreover, the species differ in the length of hibernation, the time of clutch laying or the manner of their placement in water. Many reproductive isolation barriers exist between true frog species inhabiting the Czech Republic which prevent the successful inter-species breeding. Key words: hibernation, calling, reproduction, amplexus, clutches, metamorphoses
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New findings of physiological and ecological aspects of hibernating bats
Ungrová, Zdislava ; Jahelková, Helena (advisor) ; Lučan, Radek (referee)
Bats can be found in almost all climatic zones. They have to deal with unfavorable conditions of environment to survive and reproduce sucessfully. Especially in temperate zones they have to deal with cold temperatures and lack of food during a winter season. To save energy bats enter a short, diurnal torpor or a hibernation. Usually, hibernation lasts all winter and is disturbed by short bouts of arousals. During both hibernation and torpor a physiological changes occur in bodies of bats. Body temperature decreases from endothermic levels, metabolic rates are reduced as well as respiratory rate and pulse. These changes are mainly influenced by weight and body size, diet, ambient temperature, sex and reproductive status. With the developement of new technologies, these changes can be measured more accurately than they have been in past, whether in a field or in a laboratory. But not all physiological processes are well explained. We have little knowledge especially about mechanism of arousal from hibernation. During awakening bats are infected by fungus Geomyces destructans that affects their immune system. In Norh America fungus causes a disease called White- Nose syndrome (WNS), that is responsible for death of millions of bats, especially endangered is Myotis lucifugus. In Europe, this disease is reffered...
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